The EURL ECVAM library of reference chemicals is a catalogue of chemical lists that can be used to standardise, qualify, characterise or compare in vitro, in chimico and in silico methods and models. It contains chemical lists used in research and validation ...

Among non‐communicable diseases, CVDs are the major cause of death in Europe and worldwide, causing 32% of all deaths in the world. Experimental models are essential to understand disease mechanisms and to develop accurate diagnostic tests and novel therapies....

Biomedical research is extremely resource intensive. Therefore, monitoring its outputs and impacts can be considered a priority to gain an understanding of the most productive research avenues worth investing in. For this reason, in 2019 the European Commissi...

This highly curated knowledge base contains detailed descriptions of 183 non-animal models and recorded a sharp increase in the number of articles employing them between 2016 and 2018 compared to the 2014-2015 period. The majority of these models are based o...

This highly curated knowledge base contains detailed descriptions of 88 non-animal models being used for immunogenicity in ATMP, mostly employed to test cell therapy products. T cells from peripheral blood of healthy donors cultured in 2D conditions represent...

It is widely recognised that immuno-oncology has revolutionised cancer treatment. Nevertheless there are still major hurdles in addressing several key medical questions. Among these, there is a lack of preclinical animal models capable of mimicking patient con...

Respiratory diseases are a leading cause of death and disability worldwide. Research on human diseases relies extensively on animal models, however, effective new therapies for serious respiratory conditions are still lacking. The European Commission’s Joint R...

Breast cancer is the most common cancer among women in the European Union and worldwide. Preclinical breast cancer research currently relies on animal models, mostly rodents. However, animal models mimic limited aspects of human breast cancer. The European Com...

Neurodegenerative diseases pose major challenges for societies with rapidly aging populations. Existing therapies are limited, and only treat the symptoms. Research employing animal models in the understanding of the pathologies and to develop new drugs, fai...