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EURL ECVAM Review of non-animal models in biomedical research - Neurodegenerative Diseases

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Neurodegenerative diseases pose major challenges for societies with rapidly aging populations. Existing therapies are limited, and only treat the symptoms. Research employing animal models in the understanding of the pathologies and to develop new drugs, failed for now to discover and approve an efficient treatment for these diseases.

Therefore, JRC’s EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) launched a study to collect current and emerging non-animal models used in the field of neurodegenerative diseases. The overall aim of the current project is to provide an inventory and scientific evaluation of innovative (human-based) non-animal models/approaches currently in use for basic and applied research in the field of neurodegenerative diseases, more specifically Alzheimer’s and Parkinson’s disease.

The resulting inventory covers 567 methods, ranging from biochemical and computational approaches to different types of cell cultures or ex vivo human material. The inventory aims to contribute to the increased adoption and acceptance of alternative methods in neurodegeneration research and related fields. The work has been conducted within the context of a scientific collaboration between the JRC (Directorate for Health, Consumers and Reference Materials, Chemicals Safety and Alternative Methods Unit) and Imec, KU Leuven, VIB and VITO who received financial support through a JRC (contract ref: JRC/IPR/2017/F.3/0050/OC).

Contributors

Adelaide Dura; Laura Gribaldo; Pierre Deceuninck

How to cite

European Commission, Joint Research Centre (2026): EURL ECVAM Review of non-animal models in biomedical research - Neurodegenerative Diseases. [Dataset] doi: 10.2905/JRC.SVR1DW0 PID: http://data.europa.eu/89h/a8fd26ef-b113-47ab-92ba-fd2be449c7eb

Keywords

biomedicalneurodegenerative diseasesnon-animal

Data access

Review of Non-animal Models in Biomedical Research - Neurodegenerative Diseases
Excel XLSX

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Downloadable file

A downloadable file for the dataset.

Use conditions
European Commission reuse notice

According to the European Commission reuse notice, reuse is authorised, provided the source is acknowledged. The reuse policy of the European Commission is implemented by the Decision of 12 December 2011. The general principle of reuse can be subject to conditions which may be specified in individual copyright notices. Therefore users are advised to refer to the copyright notices of the individual websites maintained under Europa and of the individual documents. Reuse is not applicable to documents subject to intellectual property rights of third parties.

Access conditions
No limitations

Anybody can directly and anonymously access the data, without being required to register or authenticate.

  • This dataset contains 567 non-animal models in the field of Neurodegenerative Diseases, including information on their applications, biological relevance, diseases area, and level of throughput. This collection aims to cover all existing and in-development non-animal approaches to neurodegenerative diseases modelling, including in vitro, in silico and ex vivo approaches.

Publications

Publication
Advanced Non-animal Models in Biomedical Research: neurodegenerative diseases: Executive Summary
Witters, H., Verstraelen, S., Aerts, L., Miccoli, B., Delahanty, A., Dura, A., Gribaldo, L. and Whelan, M., Advanced Non-animal Models in Biomedical Research: neurodegenerative diseases: Executive Summary, EUR 30334 EN, Publications Office of the European Union, Luxembourg, 2021, ISBN 978-92-76-35947-0 (online),978-92-76-35946-3 (print), doi:10.2760/005446 (online),10.2760/84181 (print), JRC124723.
Publication
Advanced Non-animal Models in Biomedical Research: neurodegenerative diseases
Witters, H., Verstraelen, S., Aerts, L., Miccoli, B., Delahanty, A., Dura, A., Gribaldo, L. and Whelan, M., Advanced Non-animal Models in Biomedical Research: neurodegenerative diseases, EUR 30334 EN, Publications Office of the European Union, Luxembourg, 2021, ISBN 978-92-76-35944-9 (online),978-92-76-35945-6 (print), doi:10.2760/386 (online),10.2760/093006 (print), JRC124723.

Temporal coverage

From date To date
2013-01-01 2018-12-31

Additional information

Published by
European Commission, Joint Research Centre
Contact email
jrc-f3-enquiries (at) ec.europa.eu
Update frequency
irregular

The event occurs at uneven intervals.

Language(s)
English

English is a member of the West Germanic group of the Germanic languages. It is an official language of almost 60 sovereign states and is now a global lingua franca.It is the third-most-common native language in the world and it is widely learned as a second language.

Data theme(s)
Science and technology

dataset theme covering the domains of science and technology, with science being the systematic pursuit of knowledge through testable explanations and predictions across natural, social, and formal disciplines, and technology encompassing the collective techniques, skills, methods, and processes used in producing goods, providing services, or achieving objectives like scientific research

Geographical name(s)
European Union
Issued date
2021-04-28
Created date
14 Apr 2021 07:52
Modified date
27 Jul 2021 14:29
Landing page
https://ec.europa.eu/jrc/en/eurl/ecvam/knowledge-sharing-3rs/life-science-research/neurodegenerative-diseases 
Dataset identifier
http://data.europa.eu/89h/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
Other identifiers
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