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EURL ECVAM in vitro hepatocyte clearance and blood plasma protein binding dataset for 77 chemicals

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The European Commission’s Joint Research Centre (JRC) runs the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) which promotes regulatory acceptance of non-animal tests relevant to chemicals safety evaluation, through research, development and validation. In particular, EURL ECVAM engages with numerous international stakeholders to improve approaches to risk assessment, including the generation, sharing and use of non-animal data. Although not typically a regulatory requirement, information about the toxico-kinetics (TK) or biological fate of a substance, characterised by physiological processes of adsorption, distribution, metabolism and excretion (ADME), can be very valuable for predicting toxicological hazard and informing risk assessment. The ADME/TK profiling of chemicals using non-animal methods has advanced considerably in recent years to support prioritisation and screening, read-across, and potentially ab initio safety assessment. The aim of this study was to generate in vitro data on blood-plasma protein binding (relevant to adsorption) and liver hepatocyte clearance (relevant to metabolism) for a set of 77 (primarily) industrial chemicals and to use the data for TK profiling and quantitative in vitro to in vivo extrapolation (qIVIVE). The data have been exploited for a ‘next generation chemical risk assessment’ case study being developed within the context of an international cooperation between regulatory agencies and regulatory science organisations committed to Accelerating the Pace of Chemical Risk Assessment (APCRA).

Contributors

Alicia Paini; Andrew Worth; David Asturiol; Donatella Carpi; Jukka Sund; Maria Meinero; Maurice Whelan; Peter Macko; Pierre Deceuninck; Salvador Fortaner Torrent; Taina Palosaari; Thomas Cole

How to cite

Paini, Alicia; Cole, Thomas; Meinero, Maria; Fortaner Torrent, Salvator; Asturiol, Davis; Carpi, Donatella; Deceuninck, Pierre; Macko, Peter; Palosaari, Taina; Sund, Jukka; Worth, Andrew; Whelan, Maurice (2026): EURL ECVAM in vitro hepatocyte clearance and blood plasma protein binding dataset for 77 chemicals. European Commission, Joint Research Centre [Dataset] doi: 10.2905/JRC.SR09628 PID: http://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee

Data access

Data on in vitro hepatocyte clearance and blood plasma protein binding for a set of 77 chemicals
Excel XLSX

XLSX is the default file format for Excel 2007 and later workbook used for Microsoft Excel spreadsheet which features calculation, graphing tools, pivot tables and a macro programming language. XLSX is in reality a ZIP compressed archive with a directory structure of XML text documents.
Downloadable file

A downloadable file for the dataset.

Use conditions
European Commission reuse notice

According to the European Commission reuse notice, reuse is authorised, provided the source is acknowledged. The reuse policy of the European Commission is implemented by the Decision of 12 December 2011. The general principle of reuse can be subject to conditions which may be specified in individual copyright notices. Therefore users are advised to refer to the copyright notices of the individual websites maintained under Europa and of the individual documents. Reuse is not applicable to documents subject to intellectual property rights of third parties.

Access conditions
No limitations

Anybody can directly and anonymously access the data, without being required to register or authenticate.

Other resources

Methodological report
PDF

PDF – Portable Document Format – is a file format developed to present documents, including text formatting and images, in a manner independent of application software, hardware and operating systems. Based on the PostScript language, each PDF file encapsulates a complete description of a fixed-layout flat document, including the text, fonts, vector graphics, raster images and other information needed to display it. PDF was standardized as an open format and does not require any royalties for its implementation.

Use conditions
European Commission reuse notice

According to the European Commission reuse notice, reuse is authorised, provided the source is acknowledged. The reuse policy of the European Commission is implemented by the Decision of 12 December 2011. The general principle of reuse can be subject to conditions which may be specified in individual copyright notices. Therefore users are advised to refer to the copyright notices of the individual websites maintained under Europa and of the individual documents. Reuse is not applicable to documents subject to intellectual property rights of third parties.

Access conditions
No limitations

Anybody can directly and anonymously access the data, without being required to register or authenticate.

  • Report describing the methodological approach used for building the dataset.

Additional information

Published by
European Commission, Joint Research Centre
Contact email
jrc-f3-enquiries (at) ec.europa.eu
Update frequency
unknown

The event occurs with unknown regularity.

Data theme(s)
Health

dataset theme covering the domain of health which includes health conditions, diseases, treatments, healthcare services, and health policies
Science and technology

dataset theme covering the domains of science and technology, with science being the systematic pursuit of knowledge through testable explanations and predictions across natural, social, and formal disciplines, and technology encompassing the collective techniques, skills, methods, and processes used in producing goods, providing services, or achieving objectives like scientific research

Issued date
2020-05-12
Created date
12 May 2020 16:42
Modified date
14 Apr 2021 09:57
Dataset identifier
http://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee
Other identifiers
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