EURL ECVAM Review of non-animal models in biomedical research - Immunogenicity Testing of Advanced Therapy Medicinal Products (ATMP)

Adelaide Dura; Evangelos-Panagiotis Daskalopoulos; Laura Gribaldo; Pierre Deceuninck

Description

This highly curated knowledge base

contains detailed descriptions of 88 non-animal models being used for immunogenicity in ATMP, mostly employed to test cell therapy products. T cells from peripheral blood of healthy donors cultured in 2D conditions represent the main model applied to test immunogenicity. Very few studies were reporting advanced models , such as embedded cells in extracellular matrix, organoids and spheroids.

Contact

Email: jrc-f3-enquiries (at) ec.europa.eu

Contributors

Adelaide Dura
Evangelos-Panagiotis Daskalopoulos
Laura Gribaldo
Pierre Deceuninck

How to cite

Dura, Adelaide; Evangelos-Panagiotis Daskalopoulos; Gribaldo, Laura; Deceuninck, Pierre (2022): EURL ECVAM Review of non-animal models in biomedical research - Immunogenicity Testing of Advanced Therapy Medicinal Products (ATMP). European Commission, Joint Research Centre (JRC) [Dataset] PID: http://data.europa.eu/89h/c1c15110-2338-422e-a228-d3f8e19262c3

Keywords

advanced therapy medicinal products (ATMP) immunogenicity non-animal

Data access

Review of advanced non-animal models for Immunogenicity Testing of Advanced Therapy Medicinal Products (ATMP)

Use conditions: European Commission reuse notice
Access conditions: No limitations

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Review of advanced non-animal models for Immunogenicity Testing of Advanced Therapy Medicinal Products (ATMP)-The JRC’s EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) conducted a study to systematically review the state-of-the art of advanced non-animal models used in immunogenicity testing for ATMPs. The majority of the 88 models that were identified, focused on in vitro (with a limited amount of in silico) techniques and mostly included the investigation of cell therapy products. Furthermore, most of the identified methods were of low throughput and low content and based on classical 2D primary cell cultures. This review highlights an urgent need for the development and acceptance of more sophisticated and innovative non-animal approaches in this e field of immunogenicity testing for ATMPs, which will pave the way for the broader use of ATMPs in the clinic.

Publications

Publication

Advanced Non-animal Models in Biomedical Research — Immunogenicity Testing of Advanced Therapy Medicinal Products (ATMP)

Canals, J. M., Romania, P., Belio-Mairal P., Nic, M., Dibusz, K., Novotny, T., Busquet, F., Rossi, F., Straccia, M., Daskalopoulos, E. P., and Gribaldo, L., Advanced Non-animal Models in Biomedical Research – Immunogenicity testing for advanced therapy medicinal products, EUR 30334/4 EN, Publications Office of the European Union, Luxembourg, 2022, ISBN 978-92-79-49091-3, doi:10.2760/7190, JRC126997.

DOI

10.2760/7190

Publication

Advanced Non-animal Models in Biomedical Research — Immunogenicity Testing of Advanced Therapy Medicinal Products (ATMP)-Executive Summary

Gribaldo, L., Dura, A., Daskalopoulos E.P., Straccia, M. and Whelan, M., Advanced Non-animal Models in Biomedical Research - Immunogenicity testing for advanced therapy medicinal products - Executive Summary, EUR 30334/4 EN, Publications Office of the European Union, Luxembourg, 2022, ISBN 978-92-76-49093-7, doi:10.2760/158699, JRC126997.

DOI

10.2760/158699

Temporal coverage

From date	To date
2014-01-01	2019-03-31

Additional information

Published by: European Commission, Joint Research Centre
Created date: 2022-03-23
Modified date: 2022-05-24
Issued date: 2022-03-31
Landing page: https://joint-research-centre.ec.europa.eu/eu-reference-laboratory-alternatives-animal-testing_en
Language(s): English
Data theme(s): Health, Science and technology
Update frequency: irregular
Identifier: http://data.europa.eu/89h/c1c15110-2338-422e-a228-d3f8e19262c3
Popularity: 22 Jul 2024: 1 visits