The toxicological response of a metabolic competent cell line (HepaRG) is investigated combining a high throughput workflows with automated high content imaging approach. Nine d...
Description
The European Union is strongly committed to the Replacement, Reduction and Refinement of testing on animals (the 'Three Rs') as reflected in Directive 2010/63/EU on the protection of animals used for scientific purposes.
As mandated by the Directive, the Joint Research Centre (JRC) runs the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) which has the following duties: coordination and promotion of the development and use of alternative methods, including in the areas of basic and applied research and regulatory testing; coordination of the validation of alternative approaches at EU level; acting as a focal point for the exchange of information on the development of alternative approaches;
setting up, maintaining and managing public databases and information systems on alternative approaches and their state of development; and promotion of dialogue between legislators, regulators, and all relevant stakeholders, in particular, industry, biomedical scientists, consumer organisations and animal-welfare groups, with a view to the development, validation, regulatory acceptance, international recognition, and application of alternative approaches.
Contact
Datasets (31)
The Fish In Vitro Intrinsic Clearance database is an Excel™ workbook and includes fish in vitro intrinsic clearance rates derived with in-vitro methods using fish S9 fraction, hepa...
The Fish In Vivo Biotransformation database is an Excel™ workbook and includes fish in vivo biotransformation data (whole body, biotransformation rate constant (kB) estimates). The...
Among non‐communicable diseases, CVDs are the major cause of death in Europe and worldwide, causing 32% of all deaths in the world. Experimental models are essential to understand ...
Repeated dose toxicity studies in animals form the basis of chemical safety evaluations. Many parameters can be measured and analysed to assess the potential of the test chemical t...
Biomedical research is extremely resource intensive. Therefore, monitoring its outputs and impacts can be considered a priority to gain an understanding of the most productive rese...
This highly curated knowledge base contains detailed descriptions of 183 non-animal models and recorded a sharp increase in the number of articles employing them between 2016 and...
To promote the use of Organ-on-Chip (OoC) devices for regulatory applications, EURL ECVAM created a catalogue of resources for developers and end-users to support validation and qu...
This highly curated knowledge base contains detailed descriptions of 88 non-animal models being used for immunogenicity in ATMP, mostly employed to test cell therapy products. T c...
Across multiple sectors, including food, cosmetics and pharmaceutical industries, there is a need to predict the potential effects of xenobiotics. These effects are determined by t...
Chemical safety assessment requires information on both chronic and acute effects of toxicants. Traditionally, such information has been provided by a set of animal studies conduct...
It is widely recognised that immuno-oncology has revolutionised cancer treatment. Nevertheless there are still major hurdles in addressing several key medical questions. Among thes...
Respiratory diseases are a leading cause of death and disability worldwide. Research on human diseases relies extensively on animal models, however, effective new therapies for ser...
Breast cancer is the most common cancer among women in the European Union and worldwide. Preclinical breast cancer research currently relies on animal models, mostly rodents. Howev...
Neurodegenerative diseases pose major challenges for societies with rapidly aging populations. Existing therapies are limited, and only treat the symptoms. Research employing ani...
The EURL ECVAM library of reference chemicals is a catalogue of chemical lists that can be used to standardise, qualify, characterise or compare in vitro, in chimico and in silico ...
The European Commission’s Joint Research Centre (JRC) runs the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) which promotes regulatory acceptance of non-a...
The EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database is a structured master database that compiles available genotoxicity and carcinogenicity information, originat...
The survey constitued of 14 multiple answer questions, aimed to understand the stakholders' opinion on the current credibility and validity of complex in vitro models such as 3D sp...
This dataset is a publicly accessible collection of learning scenarios which have been created by education professionals for use by educators who wish to teach topics under the um...
The JRC QSAR Model Database is a historical archive providing information on the validity of Quantitative Structure-Activity Relationship (QSAR) models that were submitted to JRC's...
The ECVAM KinParDB contains kinetic parameters on 100 chemicals (pharma, pesticides, industrial chemicals as well as environmental contaminants), each of which has been or still is...
DB-ALM dataset is a publicly accessible collection of alternative method summaries and protocols. DB-ALM focuses primarily on methods submitted to EURL ECVAM for validation, and th...
The purpose of the collection of these data undertaken between June and September in 2018 was to provide a snapshot overview of education and training courses and resources on the ...
The large amount of existing nanomaterials demands for rapid and reliable ways to test their potential toxicological effect on human health, preferably by means of relevant in vitr...
In the context of the European Commission's Communication published in response to the European Citizens' Initiative "Stop Vivisection", Action 1 aimed to conduct an assessment of ...
The rodent In Vitro Intrinsic Clearance database is an Excel™ workbook and includes rodent (mouse, rat) in vitro intrinsic clearance rates derived with in vitro methods using roden...
The Rodent In Vivo Biotransformation database is an Excel™ workbook and includes rodent (mouse, rat) in vivo biotransformation data (clearance or elimination or half-life, and in m...
The supplementary materials of the Nanocomput report comprise: S1: Inventory of Quantitative Structure-Property Relationship (QSPR) and Quantitative Structure-Activity Relationship...
The EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database is a structured master database that compiles available genotoxicity and carcinogenicity data for Ames positiv...
The ChemAgora web portal provides search capabilities to chemical data from resources available online, enabling users to cross-reference the substances they are working on with bo...
Related resources (3)
- https://publications.jrc.ec.europa.eu/repository/handle/JRC108879
- https://publications.jrc.ec.europa.eu/repository/handle/JRC111744
- https://publications.jrc.ec.europa.eu/repository/handle/JRC125029
Additional information
- Published by
- European Commission, Joint Research Centre
- Created date
- 2018-12-14
- Modified date
- 2023-03-31
- Landing page
- https://ec.europa.eu/jrc/en/eurl/ecvam