This highly curated knowledge base contains detailed descriptions of 183 non-animal models and recorded a sharp increase in the number of articles employing them between 2016 and 2018 compared to the 2014-2015 period. The majority of these models are based on the use of cells, particularly primary cells, and certain models are preferentially exploited for certain types of conditions, such as in the case of ex-vivo models like biopsies for skin diseases, and stem cells in the case of type 1 diabetes.
European Commission, Joint Research Centre (2026): EURL ECVAM Review of non-animal models in biomedical research - Autoimmune diseases. [Dataset] doi: 10.2905/JRC.457CBWG PID: http://data.europa.eu/89h/700397b2-edd7-4ed6-86f7-fc1b164ed432
autoimmunityimmune systeminflammatory diseasesnon-animal
Review of advanced non-animal models for autoimmune diseases. The JRC’s EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) conducted a study to systematically review the state-of-the art of advanced non-animal models used in autoimmune diseases. The majority of the 183 models that were identified, focused on in vitro techniques and they were mostly based on primary cells from donors. Furthermore, most of the identified methods were of low throughput and low content.
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| 2014-01-01 | 2019-03-31 |
