Chemical safety assessment requires information on both chronic and acute effects of toxicants. Traditionally, such information has been provided by a set of animal studies conducted over different durations, ranging from a single dose with observation of effe...

The ChemAgora web portal provides search capabilities to chemical data from resources available online, enabling users to cross-reference the substances they are working on with both regulatory information and public chemical databases. ChemAgora is a JRC con...

The large amount of existing nanomaterials demands for rapid and reliable ways to test their potential toxicological effect on human health, preferably by means of relevant in vitro tests in order to reduce testing on animals. Combining high throughput workflo...

The European Commission’s Joint Research Centre (JRC) runs the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) which promotes regulatory acceptance of non-animal tests relevant to chemicals safety evaluation, through research, developme...

The survey constitued of 14 multiple answer questions, aimed to understand the stakholders' opinion on the current credibility and validity of complex in vitro models such as 3D spheroids, bioprinted tissues, bioreactor cultures and microphysiological systems ...

The toxicological response of a metabolic competent cell line (HepaRG) is investigated combining a high throughput workflows with automated high content imaging approach. Nine different read outs related to cell viability and mitochondrial damage are measur...

The rodent In Vitro Intrinsic Clearance database is an Excel™ workbook and includes rodent (mouse, rat) in vitro intrinsic clearance rates derived with in vitro methods using rodent S9 fraction, hepatocytes, or microsomes. There are 8648 entries for approxima...

Biomedical research is extremely resource intensive. Therefore, monitoring its outputs and impacts can be considered a priority to gain an understanding of the most productive research avenues worth investing in. For this reason, in 2019 the European Commissi...

Across multiple sectors, including food, cosmetics and pharmaceutical industries, there is a need to predict the potential effects of xenobiotics. These effects are determined by the intrinsic ability of the substance, or its derivatives, to interact with the ...

The Rodent In Vivo Biotransformation database is an Excel™ workbook and includes rodent (mouse, rat) in vivo biotransformation data (clearance or elimination or half-life, and in most entries additional TK parameters relating to the reported clearance value). ...

The ECVAM KinParDB contains kinetic parameters on 100 chemicals (pharma, pesticides, industrial chemicals as well as environmental contaminants), each of which has been or still is used in various ECVAM validation programs. The database is searchable for names...

This dataset is a publicly accessible collection of learning scenarios which have been created by education professionals for use by educators who wish to teach topics under the umbrella of the Three Rs and alternative methods. The collection covers university...

The supplementary materials of the Nanocomput report comprise: S1: Inventory of Quantitative Structure-Property Relationship (QSPR) and Quantitative Structure-Activity Relationship (QSAR) models (Excel workbook) S2: Model inventories for physiologically based ...

This highly curated knowledge base contains detailed descriptions of 88 non-animal models being used for immunogenicity in ATMP, mostly employed to test cell therapy products. T cells from peripheral blood of healthy donors cultured in 2D conditions represent...

This highly curated knowledge base contains detailed descriptions of 183 non-animal models and recorded a sharp increase in the number of articles employing them between 2016 and 2018 compared to the 2014-2015 period. The majority of these models are based o...

Repeated dose toxicity studies in animals form the basis of chemical safety evaluations. Many parameters can be measured and analysed to assess the potential of the test chemical to cause adverse effects in the test animals and predict potential adverse effect...

Breast cancer is the most common cancer among women in the European Union and worldwide. Preclinical breast cancer research currently relies on animal models, mostly rodents. However, animal models mimic limited aspects of human breast cancer. The European Com...

The EURL ECVAM library of reference chemicals is a catalogue of chemical lists that can be used to standardise, qualify, characterise or compare in vitro, in chimico and in silico methods and models. It contains chemical lists used in research and validation ...

Respiratory diseases are a leading cause of death and disability worldwide. Research on human diseases relies extensively on animal models, however, effective new therapies for serious respiratory conditions are still lacking. The European Commission’s Joint R...