Organisation: European Commission, Joint Research Centre
Point of contact:

Title: EURL ECVAM Fish In Vitro Intrinsic Clearance Database


The Fish In Vitro Intrinsic Clearance database is an Excel™ workbook and includes fish in vitro intrinsic clearance rates derived with in-vitro methods using fish S9 fraction, hepatocytes, or microsomes. There are approximately 960 entries for 232 unique chemicals. The database has been compiled by ARC Arnot Research and Consulting Inc (Toronto, Canada) for EURL ECVAM (Joint Research Centre, F.3; contract number: CCR.F.C931336.X0) applying quality criteria as outlined in the spreadsheets. The EURL ECVAM Fish In Vitro Intrinsic Clearance database supports the two OECD test guidelines using cryopreserved hepatocytes (OECD TG 319A; or S9 fractions (OECD TG 319B; from rainbow trouts to determine in vitro intrinsic clearance. The test guidelines are accompanied by a guidance document (OECD GD 280; ...

Marlies Halder 0000-0002-9442-3463
Alfonso Lostia
Aude Kienzler
How to cite
Halder, Marlies; Lostia, Alfonso; Kienzler, Aude (2018):  EURL ECVAM Fish In Vitro Intrinsic Clearance Database. European Commission, Joint Research Centre (JRC) [Dataset] PID:
Related resources

Data access


  • publication Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial


Additional information
Last modified 2018-11-06
Issue date 2018-05-02
Landing page
Geographic area World
Temporal coverage

From: 2017-01-01 – To: 2018-03-15

Update frequency irregular
Language English
Data theme(s) Science and technology
EuroVoc domain(s) 36 SCIENCE

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