EURL ECVAM Fish In Vitro Intrinsic Clearance Database

Marlies Halder; Alfonso Lostia; Aude Kienzler

Description

The Fish In Vitro Intrinsic Clearance database is an Excel™ workbook and includes fish in vitro intrinsic clearance rates derived with in-vitro methods using fish S9 fraction, hepatocytes, or microsomes. There are approximately 960 entries for 232 unique chemicals. The database has been compiled by ARC Arnot Research and Consulting Inc (Toronto, Canada) for EURL ECVAM (Joint Research Centre, F.3; contract number: CCR.F.C931336.X0) applying quality criteria as outlined in the spreadsheets. The EURL ECVAM Fish In Vitro Intrinsic Clearance database supports the two OECD test guidelines using cryopreserved hepatocytes (OECD TG 319A; https://doi.org/10.1787/9789264303218-en) or S9 fractions (OECD TG 319B;

https://doi.org/10.1787/9789264303232-en) from rainbow trouts to determine in vitro intrinsic clearance. The test guidelines are accompanied by a guidance document (OECD GD 280; http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV%2FJM%2FMONO%282018%2912&doclanguage=en).

Contact

Email: clemens.wittwehr (at) ec.europa.eu

Contributors

Marlies Halder

0000-0002-9442-3463
Alfonso Lostia
Aude Kienzler

How to cite

Halder, Marlies; Lostia, Alfonso; Kienzler, Aude (2018): EURL ECVAM Fish In Vitro Intrinsic Clearance Database. European Commission, Joint Research Centre (JRC) [Dataset] PID: http://data.europa.eu/89h/jrc-eurl-ecvam-fish-in-vitro-intr-clear-db

Keywords

fish in vitro intrinsic clearance

Data access

EURL ECVAM Fish In Vitro Intrinsic Clearance Database

Use conditions: European Commission reuse notice
Access conditions: No limitations

Download

Excel workbook: EURL_ECVAM_Fish_InVitro_Intrinsic Clearance_DB.xlsx

Publications

Publication

Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

Halder, Marlies; Lostia, Alfonso; Kienzler, Aude

DOI

10.1093/toxsci/kfy113

Geographic areas

World

Temporal coverage

From date	To date
2017-01-01	2018-03-15

Additional information

Published by: European Commission, Joint Research Centre
Created date: 2018-12-14
Modified date: 2023-11-13
Issued date: 2018-05-02
Landing page: https://ec.europa.eu/jrc/en/research-topic/alternatives-animal-testing-and-safety-assessment-chemicals
Language(s): English
Data theme(s): Science and technology
Update frequency: irregular
Identifier: http://data.europa.eu/89h/jrc-eurl-ecvam-fish-in-vitro-intr-clear-db
Popularity