DATASET

EURL ECVAM Fish In Vitro Intrinsic Clearance Database

Collection: EURL-ECVAM : European Union Reference Laboratory for Alternatives to Animal Testing 

Description

The Fish In Vitro Intrinsic Clearance database is an Excelâ„¢ workbook and includes fish in vitro intrinsic clearance rates derived with in-vitro methods using fish S9 fraction, hepatocytes, or microsomes. There are approximately 960 entries for 232 unique chemicals. The database has been compiled by ARC Arnot Research and Consulting Inc (Toronto, Canada) for EURL ECVAM (Joint Research Centre, F.3; contract number: CCR.F.C931336.X0) applying quality criteria as outlined in the spreadsheets. The EURL ECVAM Fish In Vitro Intrinsic Clearance database supports the two OECD test guidelines using cryopreserved hepatocytes (OECD TG 319A; https://doi.org/10.1787/9789264303218-en) or S9 fractions (OECD TG 319B;

https://doi.org/10.1787/9789264303232-en) from rainbow trouts to determine in vitro intrinsic clearance. The test guidelines are accompanied by a guidance document (OECD GD 280; http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV%2FJM%2FMONO%282018%2912&doclanguage=en).

Contact

Email
marlies.halder (at) ec.europa.eu

Contributors

How to cite

Halder, Marlies; Lostia, Alfonso; Kienzler, Aude (2018): EURL ECVAM Fish In Vitro Intrinsic Clearance Database. European Commission, Joint Research Centre (JRC) [Dataset] PID: http://data.europa.eu/89h/jrc-eurl-ecvam-fish-in-vitro-intr-clear-db

Keywords

fish in vitro intrinsic clearance

Data access

EURL ECVAM Fish In Vitro Intrinsic Clearance Database
Download 
  • Excel workbook: EURL_ECVAM_Fish_InVitro_Intrinsic Clearance_DB.xlsx

Publications

Publication
Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

Geographic areas

World

Temporal coverage

From date To date
2017-01-01 2018-03-15

Additional information

Published by
European Commission, Joint Research Centre
Created date
2018-12-14
Modified date
2018-12-20
Issued date
2018-05-02
Landing page
https://ec.europa.eu/jrc/en/research-topic/alternatives-animal-testing-and-safety-assessment-chemicals 
Language(s)
English
Data theme(s)
Science and technology
Update frequency
irregular
Identifier
http://data.europa.eu/89h/jrc-eurl-ecvam-fish-in-vitro-intr-clear-db
Popularity
24 Jul 2022: 1 visits