The toxicological response of a metabolic competent cell line (HepaRG) is investigated combining a high throughput workflows with automated high content imaging approach. Nine different read outs related to cell viability and mitochondrial damage are measur...

To promote the use of Organ-on-Chip (OoC) devices for regulatory applications, EURL ECVAM created a catalogue of resources for developers and end-users to support validation and qualification of these new technologies. The catalogue contains a curated list of ...

Chemical safety assessment requires information on both chronic and acute effects of toxicants. Traditionally, such information has been provided by a set of animal studies conducted over different durations, ranging from a single dose with observation of effe...

The European Commission’s Joint Research Centre (JRC) runs the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) which promotes regulatory acceptance of non-animal tests relevant to chemicals safety evaluation, through research, developme...

The large amount of existing nanomaterials demands for rapid and reliable ways to test their potential toxicological effect on human health, preferably by means of relevant in vitro tests in order to reduce testing on animals. Combining high throughput workflo...