The toxicological response of a metabolic competent cell line (HepaRG) is investigated combining a high throughput workflows with automated high content imaging approach. Nine different read outs related to cell viability and mitochondrial damage are measur...

The Fish In Vitro Intrinsic Clearance database is an Excel™ workbook and includes fish in vitro intrinsic clearance rates derived with in-vitro methods using fish S9 fraction, hepatocytes, or microsomes. There are approximately 960 entries for 232 unique chemi...

The Fish In Vivo Biotransformation database is an Excel™ workbook and includes fish in vivo biotransformation data (whole body, biotransformation rate constant (kB) estimates). There are 1535 entries for 702 organic chemicals. The database has been compiled by...

Among non‐communicable diseases, CVDs are the major cause of death in Europe and worldwide, causing 32% of all deaths in the world. Experimental models are essential to understand disease mechanisms and to develop accurate diagnostic tests and novel therapies....

Repeated dose toxicity studies in animals form the basis of chemical safety evaluations. Many parameters can be measured and analysed to assess the potential of the test chemical to cause adverse effects in the test animals and predict potential adverse effect...

Biomedical research is extremely resource intensive. Therefore, monitoring its outputs and impacts can be considered a priority to gain an understanding of the most productive research avenues worth investing in. For this reason, in 2019 the European Commissi...

This highly curated knowledge base contains detailed descriptions of 183 non-animal models and recorded a sharp increase in the number of articles employing them between 2016 and 2018 compared to the 2014-2015 period. The majority of these models are based o...

To promote the use of Organ-on-Chip (OoC) devices for regulatory applications, EURL ECVAM created a catalogue of resources for developers and end-users to support validation and qualification of these new technologies. The catalogue contains a curated list of ...

This highly curated knowledge base contains detailed descriptions of 88 non-animal models being used for immunogenicity in ATMP, mostly employed to test cell therapy products. T cells from peripheral blood of healthy donors cultured in 2D conditions represent...

Across multiple sectors, including food, cosmetics and pharmaceutical industries, there is a need to predict the potential effects of xenobiotics. These effects are determined by the intrinsic ability of the substance, or its derivatives, to interact with the ...

Chemical safety assessment requires information on both chronic and acute effects of toxicants. Traditionally, such information has been provided by a set of animal studies conducted over different durations, ranging from a single dose with observation of effe...

It is widely recognised that immuno-oncology has revolutionised cancer treatment. Nevertheless there are still major hurdles in addressing several key medical questions. Among these, there is a lack of preclinical animal models capable of mimicking patient con...

Respiratory diseases are a leading cause of death and disability worldwide. Research on human diseases relies extensively on animal models, however, effective new therapies for serious respiratory conditions are still lacking. The European Commission’s Joint R...

Breast cancer is the most common cancer among women in the European Union and worldwide. Preclinical breast cancer research currently relies on animal models, mostly rodents. However, animal models mimic limited aspects of human breast cancer. The European Com...

Neurodegenerative diseases pose major challenges for societies with rapidly aging populations. Existing therapies are limited, and only treat the symptoms. Research employing animal models in the understanding of the pathologies and to develop new drugs, fai...

The EURL ECVAM library of reference chemicals is a catalogue of chemical lists that can be used to standardise, qualify, characterise or compare in vitro, in chimico and in silico methods and models. It contains chemical lists used in research and validation ...

The European Commission’s Joint Research Centre (JRC) runs the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) which promotes regulatory acceptance of non-animal tests relevant to chemicals safety evaluation, through research, developme...

The EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database is a structured master database that compiles available genotoxicity and carcinogenicity information, originating from different sources, for substances tested in the bacterial reverse mutat...

The survey constitued of 14 multiple answer questions, aimed to understand the stakholders' opinion on the current credibility and validity of complex in vitro models such as 3D spheroids, bioprinted tissues, bioreactor cultures and microphysiological systems ...