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  • CONTRIBUTORS Palosaari Taina Whelan Maurice
  • KEYWORDS in vitro toxicity,acute to chronic extrapolation,live cell,high content imaging,chronicity index
  • SCIENCE AREAS Health and consumer protection
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Time and Concentration Responses of HepaRG

Chemical safety assessment requires information on both chronic and acute effects of toxicants. Traditionally, such information has been provided by a set of animal studies conducted over different durations, ranging from a single dose with observation of effe...