Last updated: 24 Oct 2023 | Recent visits: 26 E URL-ECVAM EURL ECVAM Review of non-animal models in biomedical research - Cardiovascular diseases Among non‐communicable diseases, CVDs are the major cause of death in Europe and worldwide, causing 32% of all deaths in the world. Experimental models are essential to understand disease mechanisms and to develop accurate diagnostic tests and novel therapies.... WEB PUB DWN
Last updated: 18 Nov 2022 | Recent visits: 10 E URL-ECVAM EURL ECVAM Review of non-animal models in biomedical research - Autoimmune diseases This highly curated knowledge base contains detailed descriptions of 183 non-animal models and recorded a sharp increase in the number of articles employing them between 2016 and 2018 compared to the 2014-2015 period. The majority of these models are based o... WEB PUB DWN
Last updated: 24 May 2022 | Recent visits: 13 E URL-ECVAM EURL ECVAM Review of non-animal models in biomedical research - Immunogenicity Testing of Advanced Therapy Medicinal Products (ATMP) This highly curated knowledge base contains detailed descriptions of 88 non-animal models being used for immunogenicity in ATMP, mostly employed to test cell therapy products. T cells from peripheral blood of healthy donors cultured in 2D conditions represent... WEB PUB DWN
Last updated: 11 Aug 2021 | Recent visits: 9 E URL-ECVAM EURL ECVAM Review of non-animal models in biomedical research - Immuno-oncology It is widely recognised that immuno-oncology has revolutionised cancer treatment. Nevertheless there are still major hurdles in addressing several key medical questions. Among these, there is a lack of preclinical animal models capable of mimicking patient con... WEB PUB DWN
Last updated: 27 Jul 2021 | Recent visits: 14 E URL-ECVAM EURL ECVAM Review of non-animal models in biomedical research - Respiratory tract diseases Respiratory diseases are a leading cause of death and disability worldwide. Research on human diseases relies extensively on animal models, however, effective new therapies for serious respiratory conditions are still lacking. The European Commission’s Joint R... WEB PUB DWN
Last updated: 27 Jul 2021 | Recent visits: 6 E URL-ECVAM EURL ECVAM Review of non-animal models in biomedical research - Breast Cancer Breast cancer is the most common cancer among women in the European Union and worldwide. Preclinical breast cancer research currently relies on animal models, mostly rodents. However, animal models mimic limited aspects of human breast cancer. The European Com... WEB PUB DWN
Last updated: 27 Jul 2021 | Recent visits: 6 E URL-ECVAM EURL ECVAM Review of non-animal models in biomedical research - Neurodegenerative Diseases Neurodegenerative diseases pose major challenges for societies with rapidly aging populations. Existing therapies are limited, and only treat the symptoms. Research employing animal models in the understanding of the pathologies and to develop new drugs, fai... WEB PUB DWN
