EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database of Ames Negative Chemicals

By using a harmonised format to capture the information, the database now contains information of available in vitro and in vivo genotoxicity, and carcinogenicity results for 211 substances. All the substances are defined by Chemical name, CAS number, InChiKey code, Smile and log P and available results for the following tests: in vitro genotoxicity: mouse lymphoma Tk+/− mutation assay and Hprt mutation assay (MCGM), micronucleus test (MNvit) and chromosome aberration test (CAvit). in vivo genotoxicity: micronucleus test (MNviv), chromosome aberration test (CAviv), transgenic rodent study (TGR), unscheduled DNA synthesis (UDSviv), Cometviv (DNA damage including comet and alkaline elution). Carcinogenicity: rodent carcinogenicity and IARC classification where assigned. In addition, the database contains list of consulted sources and references. Detailed information on the data and construction of the database are reported in Madia et al. 2020 https://doi.org/10.1016/j.mrgentox.2020.503199, recently published in Mutation Research - Genetic Toxicology and Environmental Mutagenesis journal.