FIGARO-REG is a multi-regional input-output (MRIO) table, a comprehensive economic database that covers 240 EU regions (NUTS2), 48 non-EU regions (Norway and United Kingdom), and 16 main non-EU trading actors, with data for 56 industries. It is fully consistent with the Eurostat’s FIGARO (inter-country) input-output tables of the year 2017. FIGARO-REG tables encompass a complete description of all bilateral trade flows between 288 NUTS2 EU regions, for intermediate and final uses, as well as with other non-EU countries. They can be used to perform detailed assessments of value added, trade and employment impacts in EU regions with a high level of precision and granularity.