Organisation: European Commission, Joint Research Centre
Point of contact: raffaella.corvi@ec.europa.eu

Title: EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database of Ames Positive Chemicals

Description

The EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database is a structured master database that compiles available genotoxicity and carcinogenicity data for Ames positive chemicals originating from different sources. By using a harmonised format to capture the information, this database represents a powerful resource for data analysis that can be used to guide a thorough evaluation of genotoxicity and carcinogenicity. The database is intended as a resource for evaluating the predictivity of the Ames test for in vivo genotoxicity and carcinogenicity when considered alone or in association with in vitro mammalian cell assays (gene mutation and clastogenicity/aneugenicity) and for better characterisation of those cases where the Ames test leads to irrelevant ('false positive') results. The database may also serve as a platform for detailed structural characterisation of specific groups of compounds with or without carcinogenic or genotoxic activity. Available here is also the ...

Contributors
Raffaella Corvi raffaella.corvi@ec.europa.eu
Federica Madia federica.madia@ec.europa.eu
How to cite
Corvi, Raffaella; Madia, Federica (2018):  EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database of Ames Positive Chemicals. European Commission, Joint Research Centre (JRC) [Dataset] PID: http://data.europa.eu/89h/jrc-eurl-ecvam-genotoxicity-carcinogenicity-ames
Keywords
Related resources

Data access

Publications

  • publication Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? II. Construction and analysis of a consolidated database

    Kirkland D, Zeiger E, Madia F, Corvi R. Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity II. Construction and analysis of a consolidated database. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 775-776; 2014. p. 69-80. JRC91332

    DOI:10.1016/j.mrgentox.2014.10.006

  • publication Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity?: I. Reports of individual databases presented at an EURL ECVAM Workshop

    Kirkland D, Zeiger E, Madia F, Gooderham N, Kasper P, Lynch A, Morita T, Ouedraogo G, Parra Morte J, Pfuhler S, Rogiers V, Schulz M, Thybaud V, Van Benthem J, Vanparys P, Worth A, Corvi R. Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity: I. Reports of individual databases presented at an EURL ECVAM Workshop. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 775-776; 2014. p. 55-68. JRC91204

    DOI:10.1016/j.mrgentox.2014.10.005

Other resources

Additional information
Issue date 2018-02-05
Landing page https://ec.europa.eu/jrc/en/scientific-tool/eurl-ecvam-genotoxicity-and-carcinogenicity-consolidated-database-ames-positive-chemicals
Geographic area America, Asia, Antarctica, Africa, Europe, Oceania
Temporal coverage

From: 2013-01-23 – To: 2014-12-31

Update frequency irregular
Language English
Data theme(s) Economy and finance; Science and technology
EuroVoc domain(s) 36 SCIENCE; 64 PRODUCTION, TECHNOLOGY AND RESEARCH
Identifier http://data.europa.eu/89h/jrc-eurl-ecvam-genotoxicity-carcinogenicity-ames

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