Organisation: European Commission, Joint Research Centre
Point of contact: marlies.halder@ec.europa.eu

Title: EURL ECVAM Fish In Vitro Intrinsic Clearance Database

Description

The Fish In Vitro Intrinsic Clearance database is an Excel™ workbook and includes fish in vitro intrinsic clearance rates derived with in-vitro methods using fish S9 fraction, hepatocytes, or microsomes. There are approximately 960 entries for 232 unique chemicals. The database has been compiled by ARC Arnot Research and Consulting Inc (Toronto, Canada) for EURL ECVAM (Joint Research Centre, F.3; contract number: CCR.F.C931336.X0) applying quality criteria as outlined in the spreadsheets. The EURL ECVAM Fish In Vitro Intrinsic Clearance database supports the two OECD test guidelines using cryopreserved hepatocytes (OECD TG 319A; https://doi.org/10.1787/9789264303218-en) or S9 fractions (OECD TG 319B; https://doi.org/10.1787/9789264303232-en) from rainbow trouts to determine in vitro intrinsic clearance. The test guidelines are accompanied by a guidance document (OECD GD 280; ...

Contributors
Marlies Halder marlies.halder@ec.europa.eu 0000-0002-9442-3463
Alfonso Lostia alfonso.lostia@ec.europa.eu
Aude Kienzler aude.kienzler@ec.europa.eu
How to cite
Halder, Marlies; Lostia, Alfonso; Kienzler, Aude (2018):  EURL ECVAM Fish In Vitro Intrinsic Clearance Database. European Commission, Joint Research Centre (JRC) [Dataset] PID: http://data.europa.eu/89h/jrc-eurl-ecvam-fish-in-vitro-intr-clear-db
Keywords
Related resources

Data access

Publications

  • publication Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

    DOI:10.1093/toxsci/kfy113

Additional information
Last modified 2018-11-06
Issue date 2018-05-02
Landing page https://ec.europa.eu/jrc/en/research-topic/alternatives-animal-testing-and-safety-assessment-chemicals
Geographic area World
Temporal coverage

From: 2017-01-01 – To: 2018-03-15

Update frequency irregular
Language English
Data theme(s) Science and technology
EuroVoc domain(s) 36 SCIENCE
Identifier http://data.europa.eu/89h/jrc-eurl-ecvam-fish-in-vitro-intr-clear-db

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