Organisation: European Commission, Joint Research Centre
Point of contact:

Title: EURL ECVAM Fish In Vitro Intrinsic Clearance Database


The Fish In Vitro Intrinsic Clearance database is an Excel™ workbook and includes fish in vitro intrinsic clearance rates derived with in-vitro methods using fish S9 fraction, hepatocytes, or microsomes. There are approximately 960 entries for 232 unique chemicals. The database has been compiled by ARC Arnot Research and Consulting Inc (Toronto, Canada) for EURL ECVAM (Joint Research Centre, F.3; contract number: CCR.F.C931336.X0) applying quality criteria as outlined in the spreadsheets. The EURL ECVAM Fish In Vitro Intrinsic Clearance database supports the two OECD test guidelines using S9 or hepatocytes from rainbow trouts to determine in vitro intrinsic clearance. These two TGs have been approved by OECD WNT in April 2018.

Marlies Halder 0000-0002-9442-3463
Alfonso Lostia
Aude Kienzler
How to cite
Halder, Marlies; Lostia, Alfonso; Kienzler, Aude (2018):  EURL ECVAM Fish In Vitro Intrinsic Clearance Database. European Commission, Joint Research Centre (JRC) [Dataset] PID:
Related resources

Data access

Additional information
Last modified 2018-05-02
Issue date 2018-05-02
Landing page
Geographic area Africa, Oceania, Europe, Asia, America, Antarctica
Temporal coverage

From: 2017-01-01 – To: 2018-03-15

Update frequency irregular
Language English
Data theme(s) Science and technology
EuroVoc domain(s) 36 SCIENCE

Please be aware that the information and links provided in the metadata above are maintained in distributed and heterogeneous information systems. Although we strive to maintain and keep links and information updated, this may not always be possible because of changes that are not registered and updated in the relevant information systems. Please, help us to maintain the system updated by indicating broken links or any other outdated information by contacting the relevant contact point. You can also inform us using the "Contact" link of this page.