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DATASET

EURL ECVAM Review of non-animal models in biomedical research - Cardiovascular diseases

Collection: EURL-ECVAM : European Union Reference Laboratory for Alternatives to Animal Testing 

Description

Among non‐communicable diseases, CVDs are the major cause of death in Europe and worldwide, causing 32% of all deaths in the world. Experimental models are essential to understand disease mechanisms and to develop accurate diagnostic tests and novel therapies. Rodent models have been extensively exploited in basic cardiovascular research studies.Nevertheless, approximately only 25% of new drug programmes

reach market authorisation, largely because of poor predictivity in humans mostly due to a lack of efficacy or unpredicted toxicity. The JRC’s EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) has embarked on a study to identify and characterise current and emerging non-animal models and methods used in the CVD biomedical research domain.The EURL ECVAM study identified 449 publications as promising candidate methods according to carefully defined criteria.The review found that the predominant non-animal models used for CVD research are based on in silico models .As the technology and the computational power advance, in silico methods will be gaining more interest and application in a clinical context to pave the way for personalised medicine.

Contact

Email
jrc-f3-enquiries (at) ec.europa.eu

Contributors

  • Adelaide Dura
  • Evangelos-Panagiotis Daskalopoulos
  • Laura Gribaldo
  • Pierre Deceuninck

How to cite

Dura, Adelaide; Evangelos-Panagiotis Daskalopoulos; Gribaldo, Laura; Deceuninck, Pierre (2022): EURL ECVAM Review of non-animal models in biomedical research - Cardiovascular diseases. European Commission, Joint Research Centre (JRC) [Dataset] PID: http://data.europa.eu/89h/20947a04-86ef-473f-8907-c658e4050c24

Keywords

biomedical cardiovascular diseases non-animal

Data access

Review of advanced non-animal models for cardiovascular diseases
Use conditions
European Commission reuse notice 
Access conditions
No limitations 
Download 

  • This dataset contains

    449 models , ranging from biochemical and computational approaches to different types of cell cultures or ex vivo human material.

Publications

Publication
Advanced Non-animal Models in Biomedical Research: cardiovascular diseases - Executive Summary
Daskalopoulos, E. P., Gribaldo, L., Dura, A. and Whelan, M., Advanced non animal models in biomedical research – Cardiovascular diseases – Executive summary, Publications Office of the European Union, Luxembourg, 2022, doi:10.2760/185429, JRC130702.
DOI
10.2760/185429
Publication
Advanced Non-animal Models in Biomedical Research: cardiovascular diseases
Celi, S., Cioffi, M., Capellini, K., Fanni, B. M., Gasparotti, E., Vignali, E., Positano, V., Haxhiademi, D., Costa, E., Landini, L., Daskalopoulos, E. P., Piergiovanni, M. and Gribaldo, L., Advanced non animal models in biomedical research – Cardiovascular diseases, Publications Office of the European Union, Luxembourg, 2022, doi:10.2760/94608, JRC130702.
DOI
10.2760/94608

Geographic areas

European Union

Temporal coverage

From date To date
2013-01-01 2019-12-31

Additional information

Published by
European Commission, Joint Research Centre
Created date
2022-09-22
Modified date
2023-10-24
Issued date
2022-09-29
Landing page
https://joint-research-centre.ec.europa.eu/eu-reference-laboratory-alternatives-animal-testing-eurl-ecvam/life-science-research_en 
Data theme(s)
Health, Science and technology
Update frequency
irregular
Identifier
http://data.europa.eu/89h/20947a04-86ef-473f-8907-c658e4050c24
Popularity